Spain has a similar classification system to France and Italy, with all classified wine regions regulated under the Denominación de Origen (DO) system. Denominación de origen' is Spanish for 'designation of origin'

As of 2006, 72 wine regions have EU QWPSR (Quality Wine Produced in Specific Regions) status.

4 Denominación de Pago (DO de Pago): Individual single-estates with an international reputation

2 Denominación de Origen Calificada/Qualificada (DOCa/DOQ - Denominació d'Origen Qualificada in Catalan): Regions with a track record of consistent quality

59 Denominación de Origen (Denominació d'Origen in Catalan - DO): mainstream quality-wine regions

5 Vino de Calidad Producido en Región Determinada (VCPRD): a 'starter home' for wine regions climbing the quality ladder.

There are also some 55 country wine areas (Vinos de la Tierra - VdlT) which do not have EU QWPSR status but which may use a regional name.

Most DO regions are classified and regulated by how long they age the wines. On a red wine label, one may find the terms Crianza, Reserva or Gran Reserva, denoting the wine's barrel and bottle time.